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The independence of intrinsic radiosensitivity as a prognostic factor for patient response to radiotherapy of carcinoma of the cervix.

机译：固有放射敏感性作为患者对子宫颈癌放射治疗反应的预后因素的独立性。

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摘要

A study was made of the prognostic value of pretreatment measurements of tumour radiosensitivity (surviving fraction at 2 Gy, SF2) in 128 patients with stage I-III carcinomas of the uterine cervix undergoing radiotherapy. The median follow-up time was 47 months. In a univariate analysis stratifying patients according to the median value, radiosensitivity was a significant prognostic factor for overall survival, local control and metastasis-free survival. The 5-year survival rate for tumours with SF2 values below the median was 81% and was significantly greater than the rate of 51% for those with SF2 values above the median. In bivariate analyses, SF2 was shown to be independent of disease stage, tumour grade, patient age, colony-forming efficiency and tumour diameter. In a multivariate analysis, radiosensitivity was the most important variable and, after allowing for this, only stage was a significant independent predictor of treatment outcome. These data indicate that, in carcinoma of the cervix treated with radiotherapy, pretreatment tumour intrinsic radiosensitivity is an important prognostic parameter and contributes to prognosis independently of other established and putative parameters.
机译：进行了一项研究，对128例接受放射治疗的子宫颈I-III期宫颈癌患者的肿瘤放射敏感性（2 Gy，SF2的存活分数）进行预处理测量的预后价值。中位随访时间为47个月。在根据中位数对患者进行分层的单因素分析中，放射敏感性是整体生存，局部控制和无转移生存的重要预后因素。 SF2值低于中值的肿瘤的5年生存率是81％，显着高于SF2值高于中值的肿瘤的51％。在双变量分析中，SF2与疾病阶段，肿瘤等级，患者年龄，集落形成效率和肿瘤直径无关。在多变量分析中，放射敏感性是最重要的变量，考虑到这一点，只有分期是治疗结果的重要独立预测因子。这些数据表明，在用放射疗法治疗的子宫颈癌中，治疗前的肿瘤固有放射敏感性是重要的预后参数，并且与其他既定和推定参数无关地有助于预后。

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